Metal Binding Sites in Proteins
نویسندگان
چکیده
Metal ions play a critical role in living systems. About one third of proteins need to bind metal for their stability and/or function. In this review, current sequence based and structure based methods for metal binding site prediction will be presented, with emphasis on the CHED and SeqCHED methods of prediction from apo-protein structures and protein sequences having homologs (even remote) in the structural protein databank (PDB). Metal binding site prediction will be considered as a step in function assignment for new proteins. Finally, a disproportional association of first and second shell metal binding residues in human proteins with disease-related SNPs will be shown.
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